When a young woman with a hip replacement sought help for her hip problems, she was turned away from specialist hip clinics.
It was a case study in the limits of the Australian health system.
Now a research team at the University of Queensland says the key to finding the “right” spine lining can be found in the body’s natural processes.
The team says their study provides a glimpse into the way we heal and is the first to look at the influence of the lining on the health of a patient.
The new research will be published in the journal PLoS ONE.
The team of researchers, led by Dr Sarah Haggarty from the University’s School of Medicine, examined the results of over 1,200 patients who underwent hip replacement surgery over a four-year period.
They discovered that the lining was key to maintaining the healthy and strong tissue of the hip.
Dr Haggart says this study is important because we have been told that the right spine lining is the most important thing for a patient to have.
“The way that our cells work is we’re all essentially wired to the surface of the cells,” she said.
“[It’s] not a matter of the ‘surface’ but how it’s structured, what’s inside of it.”
“Our cells do not always work in the same way, they do not work as efficiently, they don’t get to know each other.”
She says the lining is an important part of the process of how cells interact with each other.
Dr Haggie said the team found that the cells of the body were able to communicate with each another in a way that is very similar to our own cells.
This is important, because it means that the process we call cell communication, which we know as signaling, is important for the functioning of cells in the whole body.
She said the research also found that this is the case for other tissues around the body, such as the skin.
So what is the lining of the heart?
In the study, Dr Hoggart said the lining came into play when the cells that make up the heart were “attached” to the bone.
At the time of hip replacement, this meant that the stem cells in a patient’s heart were already attached to the surrounding tissue and had no connection to the heart itself.
However, as the team was testing the patient’s blood flow and the levels of these cells in her heart, the team noticed that the amount of collagen found in her blood was lower.
What the team did next was to put the patient back into the bone and look at how the stem cell lining was being impacted by the stress of the surgery.
From this, they were able, with more than 80 per cent of the patients, to show that the “good” stem cells were being destroyed in the process.
But, despite these findings, the lining in the heart remained stable, Dr Mather said.
She said the fact that this lining was still present at all points in the patient was important.
One area where this study was a bit different was in its use of animal models.
Dr MATHER said it was important to have animals with different types of blood vessels to test the “what’s happening in the human body”.
“What we’ve found is that there’s a very strong effect of the bone on the lining, so the bone has to be connected to the cell.
And when it is connected, the cells are connected in a different way,” she explained.
In this study, the bone was connected to a patient with the most common type of hip problem, which was an “extended” hip.
A key finding in this study showed that the bone had a “negative feedback” effect on the collagen in the lining.
When this negative feedback effect was removed, the collagen lining in this patient was still there.
Another area where Dr MATCHY was surprised was in the way that the researchers measured the changes in collagen in different parts of the patient.
For example, there were changes in the type of bone collagen found within the lining that were not seen in other parts of her body.
She suggested that this was a consequence of the “positive feedback” mechanism being removed.
It was also interesting to see that the patients who had the most bone collagen in their lining had also had the lowest levels of bone atrophy in the bone at the time they were undergoing hip replacement.
These findings suggest that we need to do a lot more work in order to understand how these changes in bone collagen occur.
How is bone collagen affected by different types?
Dr Hoggie said that the new study revealed that the collagen found inside the bone also varied depending on the type and location of the blood vessel connecting it to the body.
“What is bone is the material that goes around the bone,” she says.
“If you have a small blood vessel, it’s not very flexible